| risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 | breast,ovarian, |
| These observations are consistent with the idea that BRCA2, but not BRCA1, is a tumor suppressor of prostate cancer. | prostate, |
| Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection. | breast, |
| The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. | breast, |
| Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor. | pancreatic, |
| three patients had biallelic inactivation of BRCA2, a tumor suppressor gene critical for homologous DNA repair. two had germline BRCA2 mutations. The third patient had somatic BRCA2 homozygous copy loss. Biallelic BRCA2 inactivation in Metastatic Castration-resistant Prostate Cancer warrants further exploration as a predictive biomarker for sensitivity to platinum c | prostate, |
| Data indicate that pathogenic mutations were found in 13/47 (28%) ovarian cancers: eight in BRCA1 and five in BRCA2 tumor suppressor proteins. | ovarian, |
| Individual deletion of Palb2, Brca1 or Brca2 genes in pancreas per se using Pdx1-Cre was insufficient to cause tumors, but it reduced pancreata size. Concurrent expression of mutant KrasG12D and p53R270H, with tumor suppressor inactivated strains in Palb2-KPC, Brca1-KPC or Brca2-KPC, accelerated pancreatic ductal adenocarcinoma (PDAC) development. | pancreatic, |
| Phytoestrogen-rich diets modulate expression of Brca1 and Brca2 tumor suppressor genes in mammary glands of female Wistar rats. | None |
| Molecular genetic analysis of the BRCA2 tumor suppressor gene region in cutaneous squamous cell carcinomas. | None |
| CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis. | None |
| Evidence that the tumor-suppressor protein BRCA2 does not regulate cytokinesis in human cells. | None |
| A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor. | None |
| the models reveal novel aspects of cancer evolution in carriers of germline BRCA2 mutations, provide new insights into the tumour suppressive role of BRCA2 | None |
| PCAT-1 expression produces a functional deficiency in homologous recombination through its repression of the BRCA2 tumor suppressor. | None |
| The article summarizes the multiple functions for BRCA2 in the preservation of chromosome stability which explain its tumour suppressive function. [review] | None |
| this study argues that tumor suppression by BRCA1 and BRCA2 originates from their fundamental role in controlling the assembly and activity of macromolecular complexes that monitor chromosome duplication, maintenance, and segregation across the cell cycle. | None |
| Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. | None |