| These findings support the concept that STAT1 exerts its tumor suppressor effects in esophageal squamous cell carcinoma via modulating the expression of key regulators of apoptosis and cell-cycle progression. | esophageal, |
| Results show that high ph-STAT1 and ph-STAT3 tumor cell expression were associated with increased ER and PR, reduced tumor grade and necrosis. STAT1 and STAT3 expression appeared to be an important determinant of favorable outcome in patients with invasive ductal breast cancer suggesting that both act as tumor suppressor proteins in patients with ductal breast cancer. | breast, |
| These data demonstrate that epithelial STAT1 is a male-specific tumor suppressor in colorectal cancer of mice and humans. | colorectal, |
| STAT1 plays a pivotal role as a tumor suppressor in glioma. | glioma, |
| STAT1/IRF1 is a key growth inhibitory and tumor suppressive signaling pathway that prevents mammary cancer formation by maintaining growth control. | None |
| our findings show how the phosphorylation status of STAT1 determines its function as a tumor suppressor | None |
| The STAT1 suppresses tumor formation in mammary glands by preventing the natural developmental function of a growth factor signaling pathway from becoming pro-oncogenic. | None |
| findings suggest that the identified STAT1/ASPP2 pathway may connect tumor suppression and cell polarity to neuroinflammation | None |
| STAT1b plays a key role in enhancing the tumor suppressor function of STAT1a, in ESCC, in a manner that can be amplified by IFN-gamma | None |
| Integrin alpha5beta6 down-regulation causes a significant increase in donor cancer cells, and their exosomes, of two molecules that have a tumor suppressive role, STAT1 and MX1. | None |