| Stat3 is a potent oncogenic molecule that plays a role in formation of lung adenocarcinomas in both mice and humans. | lung, |
| STAT3 protein has a major role in the oncogenic process of nasal-type NK-cell lymphomas, and may represent a promising therapeutical target. | lymphoma, |
| Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis. | liver, |
| Stat3 induces oncogenic Skp2 expression in human cervical carcinoma cells. | cervical, |
| STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. | lung, |
| Kaposi s sarcoma-associated herpesvirus kaposin B induces unique monophosphorylation of STAT3 at serine 727 and MK2-mediated inactivation of the STAT3 transcriptional repressor TRIM28. | sarcoma, |
| STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia. | leukemia, |
| STAT3 is overexpressed and overactive diffuse large B-cell lymphoma and STAT3 binding associates with oncogenic pathways. | lymphoma, |
| findings simultaneously reveal how EBV manipulates host STAT3 even before expression of viral oncogenes to facilitate cell survival and proliferation, processes fundamental to EBV lymphomagenesis | lymphoma, |
| XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer. | breast, |
| these data demonstrate that XPO1 inhibition by SINE compounds represses STAT3 transactivation to block the selective oncogenic properties of survivin and supports their clinical use in triple-negative breast cancer . | breast, |
| Treatment with IL-22 protects against renal ischemia-reperfusion injury by activating STAT3 and AKT proto-oncogene protein. | kidney, |
| RKIP synergizes with microtubule inhibitors to induce apoptosis and inhibit STAT3 activation of breast and prostate cancer cells. RKIP plays a critical role in opposing the effects of pro-oncogenic STAT3 activation. | breast,prostate, |
| MicroRNA-19a functions as an oncogenic microRNA in non-small cell lung cancer by targeting the suppressor of cytokine signaling 1 and mediating STAT3 activation. | lung, |
| Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. | lymphoma, |
| The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3beta in Esophageal Squamous Cell Carcinoma. | esophageal, |
| Exosomes from patient-derived ascites ovarian cancer cell lines cultured under hypoxic conditions carried more potent oncogenic proteins-STAT3. | ovarian, |
| PCNA functions as an oncogene in the progression of NSCLC through up-regulation of STAT3. | lung, |
| The LINC00518 acts as an oncogene in cervical cancer (CC) via regulation of the JAK/STAT3 signaling pathway. | cervical, |
| The present results revealed that the JAK3/STAT3 oncogenic pathway and PRDM1 expression could stratify clinicopathologic features of extranodal NK/Tcell lymphoma, nasal type (ENNK/TNT). | lymphoma, |