| STAT3 has this dual role in tumour inflammation and immunity by promoting pro-oncogenic inflammatory pathways. | None |
| Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein. | None |
| the cdk5-STAT3 oncogenic pathway plays an important role in the expression of DNA repair genes and that these proteins could be used as predictive markers of tumors that will fail to respond to chemotherapy. | None |
| Data show that STAT3alpha may therefore be a common mediator of oncogenic signaling pathways stimulating progression of EC. | None |
| Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity. | None |
| Data identified the oncogenic transcription factor STAT3 as a binding partner of nuclear survivin. | None |
| MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. | None |
| Essential role of Stat3 in PI3K-induced oncogenic transformation. | None |
| STAT3 may exert its oncogenic effect by up-regulating transcription of genes involved in promoting growth and proliferation, but also by down-regulating expression of negative regulators of the same cellular processes, such as Necdin. | None |
| stat3, a known oncogene and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos. | None |
| STAT3, essential factor for tumor growth/progression, can act as a first hit in multistep carcinogenesis; this ability to predispose cells to malignant transformation may be relevant in the pro-oncogenic niche represented by chronically inflamed tissues. | None |
| A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip. | None |
| STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6. | None |
| Kaposin B significantly contributes to the chronic inflammatory environment by unique activation of the proto-oncogene STAT3, coupled with MK2-mediated inactivation of the STAT3 transcriptional repressor TRIM28. | None |
| The Stat3 paradox: a killer and an oncogene. | None |
| How should we define STAT3 as an oncogene and as a potential target for therapy?. | None |
| study shows that the MEK-ERK pathway is required for activated Ras-induced phosphorylation of STAT3 on S727, that inhibition of STAT3 S727 phosphorylation contributes to the anti-oncogenic potential of MEK inhibitors | None |
| This review presents the evidence for critical roles of STAT3 in oncogenesis and discusses the potential for development of novel cancer therapies based on mechanistic understanding of STAT3 signaling cascade. | None |
| tumor-specific mutational events in the PTPRT gene can serve as direct drivers for tumor growth by inducing hyperactivation of STAT3, a potent oncogenic transcription factor and PTPRT substrate | None |
| Many drug-treated oncogene-addicted cancer cells engage a positive feedback loop leading to Stat3 activation. | None |