| The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. | breast, |
| results provide direct evidence that the LKB1 tumor suppressor is the major upstream activating kinase for AMPK in liver | liver, |
| Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC). | thyroid, |
| Lkb1 is a potent suppressor of carcinogen-induced skin and lung cancers and downstream targets beyond the AMPK-mTOR pathway are likely mediators of Lkb1-dependent tumor suppression. | skin,lung, |
| The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. | lung, |
| Data shows a link between the tumor suppressor Lkb1 and prostate neoplasia, highlighting a tumor suppressive role within the mouse and raising the possibility of a similar association in the human. | prostate, |
| LKB1 is thus a major cervical tumor suppressor, demonstrating that acquired genetic alterations drive progression of HPV-induced dysplasias to invasive, lethal cancers | cervical, |
| Results place LKB1 in a coactivator role for ERalpha signaling, broadening the scientific scope of this tumor suppressor kinase and laying the groundwork for the use of LKB1 as a target for the development of new therapies against breast cancer. | breast, |
| LKB1 serine-threonine kinase is a tumor suppressor that is inactivated in a large number of sporadic human lung non-small cell carcinomas and cervical cancers. | cervical,lung, |
| Adiponectin treatment increases the expression of tumor suppressor gene, LKB1 in breast cancer cells. | breast, |
| The LKB1/AMPK/TSC tumor suppressor axis is functional in acute myeloid leukemia. | leukemia, |
| Mice deleted for the tumour suppressor LKB1 (also called STK11) in the spinal cord, some parts of the brain and in the endocrine pancreas (betaLKB1KO mice) develop hind-limb dysfunction and axon degeneration at about 7 weeks. | brain, |
| results suggest that LKB1 acts as a tumour suppressor in most sporadic cases of clear cell renal cell carcinoma and that underexpression of LKB1 is a common event in the disease | kidney, |
| This study establishes LKB1 as an important tumor suppressor in cervical cancer and sheds light on a novel signaling pathway regulated by LKB1 | cervical, |
| Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma | liver,cholangiocarcinoma, |
| Frameshift Mutations of CAB39L, an Activator of LKB1 Tumor Suppressor, in Gastric and Colorectal Cancers | gastric,colorectal, |
| Decreased Expression of Tumor-suppressor Gene LKB1 Correlates with Poor Prognosis in Human Gastric Cancer | gastric, |
| silencing of the LKB1 tumor suppressor affects the delamination of pre-migratory cephalic neural crest cells from the neural primordium as well as their polarization and survival, thus resulting in severe facial and brain defects | brain, |
| identification of a network linking metabolic and epigenetic alterations that is central to oncogenic transformation downstream of the liver kinase B1 (LKB1, also known as STK11) tumour suppressor, an integrator of nutrient availability, metabolism and growth | liver, |
| LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies | uterine, |