| Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3 | breast, |
| LKB1 performed as a tumor suppressor in lung cancer inhibiting proliferation of lung cancer cells and inducing their apoptosis. LKB1 also inhibited the in vivo growth of lung cancer. After treatment with cyclopamine, the activated Shh signaling pathway induced by LKB1 silencing was suppressed, and the inactivated Shh signaling pathway induced by LKB1 over-expression was enhanced. | lung, |
| Tumor suppressor LKB1 inhibits the progression of gallbladder carcinoma and predicts the prognosis of patients with this malignancy | bladder, |
| Tumor Suppressor LKB1 inhibits both the mRNA Expression and the Amplification of hTERC by the Phosphorylation of YAP in Lung Cancer Cells | lung, |
| Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. | None |
| Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation | None |
| Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. | None |
| The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. | None |
| LKB1 tumor suppressor protein: PARtaker in cell polarity. | None |
| LKB1, the gene mutated in Peutz-Jeghers syndrome (PJS), acts as a tumor suppressor by activating TSC2, the gene mutated in Tuberous sclerosis complex | None |
| Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translation. | None |
| LKB1 regulates GATA-mediated gene expression and that this activity of LKB1 may be important for its tumor suppressor function. | None |
| The LKB1 tumor suppressor kinase in human disease. | None |
| Phosphorylation of PAR-1 by tumor suppressor protein LKB1 is required for PAR-1 activation, which promotes tau phosphorylation. | None |
| High-level expression of functional tumor suppressor LKB1 in Escherichia coli. | None |
| Role of LKB1 as a master regulator of polarity and metabolism could contribute to its tumor suppressor function. | None |
| The molecular mechanisms that underlie the tumor suppressor function of LKB1. | None |
| LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity. | None |
| loss of function of LKB1 can accelerate proliferation in contexts where it functions as a tumor suppressor, but can also sensitize cells to metformin | None |
| REVIEW: Molecular mechanisms of tumor suppression by LKB1 | None |