| Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors. | None |
| LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells | None |
| tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases | None |
| These results suggest that LKB1 may be a cell-type specific tumor suppressor. | None |
| The tumor suppressor LKB1 is a central regulator of tumor metabolism and growth control through the regulation of HIF-1alpha-dependent metabolic reprogramming. | None |
| Results demonstrate a direct impact of altered LKB1-AMPK signalling function in EOC. In addition, this is the first evidence in cancer cells demonstrating a pro-survival function for LKB1, a kinase traditionally thought to act as a tumour suppressor. | None |
| Mutations in TP53 and STK11 also impacted tumor biology regardless of KRAS status, with TP53 strongly associated with enhanced proliferation and STK11 with suppression of immune surveillance. These findings illustrate the remarkably distinct ways through which tumor suppressor mutations may contribute to heterogeneity in KRAS-mutant tumor biology. | None |
| The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development | None |
| The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress | None |
| Controlling the master-upstream regulation of the tumor suppressor LKB1 | None |
| Differentially expressed novel alternatively spliced transcript variant of tumor suppressor Stk11 gene in mouse | None |
| the regulation of the cytoskeleton and cell polarity may contribute significantly to the tumour suppressor function of LKB1/par-4. | None |
| Oncogenic Ras cooperates with knockdown of the tumor suppressor Lkb1 by RNAi to override organ size limits in Drosophila wing tissue | None |
| these data highlighting that LKB1 is modified by SUMO-2 in clinical HCC tumors further supports a potential role for LKB1 SUMOylation as a novel oncogenic mechanism in a subtype of HCC patients. | liver, |