| analysis of cross talk between the human T-cell leukemia virus type 1 Tax transactivator and the oncogenic bHLH transcription factor TAL1 | leukemia, |
| TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells. | leukemia, |
| Data show that thymic expression of the Tal1 and Lmo2 oncogenes results in rapid development of T-ALL, and similar to T-ALL patients, more than half the leukemic mice develop spontaneous mutations in Notch1. | leukemia, |
| Aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia. | leukemia, |
| our study reveals a novel molecular mechanism involving changes in three-dimensional chromatin interactions that activate the TAL1 oncogene in human T-cell leukemia. | leukemia, |
| There is occurrence of TAL1 and MYC translocations in early thymocyte ontogeny, but subsequent oncogenic alterations were required to drive oncogenesis in T-cell acute lymphoblastic leukemia. | leukemia, |
| The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. | leukemia, |
| p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein. | None |
| Inhibition of the hTERT promoter by the proto-oncogenic protein TAL1. | None |
| Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. | None |
| Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis. | None |
| TAL1 forms a positive interconnected autoregulatory loop with GATA3 and RUNX1 and that the TAL1 complex directly activates the MYB oncogene. | None |
| study found that heterozygous somatic mutations are acquired that introduce binding motifs for the MYB transcription factor in a precise noncoding site, which creates a super-enhancer upstream of the TAL1 oncogene; MYB binds to this new site | None |
| Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. | None |
| Review emphasizes recent findings that shed light into the intricacies of TAL1 (epi)genetic regulation and the transcription network orchestrated by this major T-cell oncogene.[reiew] | None |
| Manipulation of CTCF boundary can alter TAL1 TAD and oncogenic transcription networks in leukemogenesis. | None |
| Inhibition of cellular differentiation by the SCL/tal oncoprotein: transcriptional repression by an Id-like mechanism. | None |
| Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. | None |
| Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen. | None |
| Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1. | None |