| These observations provide experimental evidence supporting a possible tumor suppressor role of HNF1A in pancreatic cancer. | pancreatic, |
| Results identified HNF1A/B as a good candidates to master the regulation of pancreatic differentiation, which at the protein level loses its expression in malignant ductal cells of the pancreas, suggesting its putative role as tumor suppressor in pancreatic cancer. | pancreatic, |
| Tumor-suppressive activity of Hnf1? in Wilms_ tumor | None |
| Lef1 and Tcf1 showed oncogenic effect in colonic carcinogenesis. Cellular context of miRNAs might play important roles in carcinogenesis by altering the expression pattern of Lef/Tcfs members. | colorectal, |
| we established an HNF1A-dependent gene signature in PDA cells that significantly correlated with reduced survivability in patients. These findings identify HNF1A as a central transcriptional regulator of PCSC properties and novel oncogene in PDA | None |