| Authors suggest that NKX2-1 as a tumour suppressor or a tumour promoter in lung adenocarcinoma progression is dependent on p53 status. | lung, |
| These findings describe recurrent NKX2-1 mutations in invasive mucinous adenocarcinomas of the lung and support NKX2-1 as a lineage-specific tumor suppressor gene in lung carcinogenesis. | lung, |
| TTF-1 may serve as a tumor suppressor gene based on its inverse correlation with Ki-67 proliferative activity and increase of cellular apoptosis | None |
| TTF-1 may serve as a tumor suppressor gene based on its inverse correlation with Ki-67 proliferative activity | None |
| Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. | lung, |
| A protein signature for Titf1/Nk x2-1, a known lineage survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. | lung, |
| data suggests that miR-365 suppresses the expression and therefore the oncogenic functions of NKX2-1 in lung cancer | lung, |
| The complexity of thyroid transcription factor 1 with both pro- and anti-oncogenic activities. | thyroid, |
| Findings suggest that the novel non-transcriptional function of TTF-1 identified in this study may contribute to lung adenocarcinoma development by conferring tolerance to DNA RS, which is known to be inherently elicited by activation of various oncogenes. | lung, |
| NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression. | None |