Sentence and cancer type
Showing 181-200 of 386 items.
SentenceCancertype
Controls the transcription of GADD45alpha and Maspin (SERPIN-B5) independently of tumor suppressor protein p53.None
p53 is a direct transcriptional target gene of hPitx1. This observation is concordant with the recent identification of hPitx1 as a tumor suppressor gene.None
ATP binding function of MDM2 can mediate its chaperone function toward the p53 tumor suppressorNone
Eliminating HSF1 protects mice from tumors induced by mutations of the RAS oncogene or a hot spot mutation in the tumor suppressor p53. In cell culture, HSF1 supports malignant transformation.None
interplay between TFIIEalpha and the tumor suppressor protein p53 in regulating transcriptional activation that may be modulated by the phosphorylation status of p53None
Genetic alterations of the p53 tumor suppressor gene were seen in a mixed serous carcinoma of the endometrium.None
The central role of p53 transactivation for cell senescence is highlighted, suggesting that transactivation is insufficient for apoptosis, while providing insight into the tumor suppressor mechanisms of p53.None
Mutation of prim1 causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor protein p53.None
Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1.None
structural analysis of the tumor suppressor p53 [review]None
Data show that the elimination of the salt bridge and the inversion of the flexibility of L1 and L3 are directly or indirectly responsible for deactivating the tumor suppressor p53.None
the human glutathione S-transferase P1 gene is a novel transcriptional target of the p53 tumor suppressor geneNone
Pubertal physical activity up-regulates tumor suppressor genes BRCA1, p53 and ER-beta, and reduced ER-alpha/ER-beta ratio in the mammary glandNone
These results establish a link between the p53 tumor suppressor and RNA processing via hnRNPA2/B1 and RNA Helicase A.None
p53 retains tumor suppressor activity in the absence of Atm.None
Sentrin-specific protease Senp1 repression induces tumor suppressor protein p53-mediated premature senescence; SUMO proteases may thus be required for proliferation of normal human cells.None
MAP1B light chain can interact with the tumor suppressor p53.None
p53 contributes to innate immunity by enhancing IFN-dependent antiviral activity independent of its functions as a proapoptotic and tumor suppressor gene.None
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.None
data link EWS-FLI1 to the NOTCH and p53 pathways and provide a plausible basis both for NOTCH tumor suppressor effects and oncogenesis of cancers that retain wild-type p53None