Sentence and cancer type
Showing 221-240 of 386 items.
SentenceCancertype
Data show that miRNA-125a translationally arrests mRNA of the p53 tumor suppressor gene based on the high degree of sequence homology between the seed sequence of miR-125a and the 3_-UTR of p53.None
Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation.None
Data show that the DmHsp22 interacts and inactivates wild type tumor suppressor protein p53, which may be one possible way of its functioning in human cells.None
Data show that loss of Bmf reduced the pressure to inactivate p53, whereas Bad deficiency did not, identifying Bmf as a novel component of the p53-independent tumor suppressor pathway triggered by c-Myc.None
The dimeric structure and the bivalent recognition of H3K4me3 by the tumor suppressor ING4 suggests a mechanism for enhanced targeting of the HBO1 complex to chromatin.None
p53 acts as a tumor suppressor and its potential role in the outcome of antimitotic chemotherapy.None
review of the tumor suppressor role of the p53 network and context-dependent nature of p53 target-gene functions [review]None
induction of Foxp3 in the context of tumor suppression is regulated in a p53-dependent manner and implicates Foxp3 as a key determinant of cell fate in p53-dependent DNA damage responsesNone
G9a and Glp methylate lysine 373 in the tumor suppressor p53None
a synergistic interaction between Parp-2 and p53 in tumour suppression through the role of Parp-2 in DNA-damage response and genome integrity surveillanceNone
p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.None
SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability.None
NS1 was able to associate with and inhibit the tumor suppressor p53 that plays an essential role in regulating apoptosis of influenza A virus-infected cells.None
tumor suppressor p53 expression was increased following EphB3 stimulation and is reduced in the absence of either EphB3 or ephrinB3.None
Mdm2 is a major negative regulator of the tumor suppressor p53 and has long been thought to inhibit p53 in two ways.None
the ability of p53 to limit aberrant self-renewal contributes to its tumor suppressor activityNone
Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activatedNone
BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice.None
These results indicate that Mfn2 is a novel p53-inducible target gene, which provides insight into the regulation of Mfn2 and its associated activities in the inhibition of cell proliferation, promotion of apoptosis, and modulation of tumor suppression.None
nuclear Bcl2L12 physically and functionally interacts with the p53 tumor suppressorNone