| In tumors with wild-type p53, its tumor suppressor function is often impaired by MDM2 overexpression that targets p53 for proteasomal degradation. Likewise, MDM2 targets HIPK2 for protein degradation impairing p53-apoptotic function. | None |
| Studies indicate that p53 regulates cellular metabolism, autophagy and many unconventional tumor suppressor activities. | None |
| phosphorylation of Ser312 is required for p53 to function fully as a tumor suppressor in vivo | None |
| threshold for loss of tumor suppressor activity in terms of the disruption of the tetrameric structure of p53 could be extremely low | None |
| Alterations in the tumor suppressor gene p16(INK4A) are associated with aggressive behavior of penile carcinomas. | None |
| Mouse double minute 2 (Mdm2) gene links genotoxic stress and metabolism to tumor suppressor, p53. (Review) | None |
| The role of p53 tumor suppressor and PARP1 in the DNA repair mechanism of immune adaptive response induced by low dose radiation is reported. | None |
| Data show that VentX is a direct transcriptional activator of p53-p21 and p16ink4a-Rb tumor suppression pathways. | None |
| apoptosis is the primary tumor suppressive p53 function and the ablation of additional p53 pleiotropic effects further exacerbates tumor progression. | None |
| The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. | None |
| Cancerous tissues from 30 patients with HPSCC were examined for LOH in 4 tumor suppressor genes (TSGs) (p16, Rb, E-cadherin, and p53) at loci 9p21, 13q21, 6q22, and 17p13, respectively, using microsatellite markers amplified by polymerase chain reaction. | None |
| Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. | None |
| The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens. | None |
| p53 transactivation is essential for tumor suppression but, intriguingly, in association with a small set of novel p53 target genes; studies distinguish the p53 transcriptional programs involved in acute DNA-damage responses and tumor suppression | None |
| downstream effectors of the p53-p21 and p16-pRB tumour suppressor pathways crucial for mediating entry into senescence | None |
| TP53 is a very important tumor suppressor gene and its product, the p53 protein, maintains DNA stability and normal cellular growth. | None |
| Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells. | None |
| This meta-analysis showed that individuals with the homozygous Pro/Pro genotype of the p53 tumour suppressor gene had increased risk of recurrent pregnancy loss | None |
| SMYD2 has a role in specifically recognizing and regulating functions of p53 tumor suppressor through Lys-370 monomethylation | None |
| Nop10 loss results in 18S rRNA processing defects and collapse of the small ribosomal subunit, coupled to stabilization of the p53 tumor suppressor protein through small ribosomal proteins binding to Mdm2. | None |