| Oncogenic splicing factor SRSF1 stabilizes the tumor suppressor protein p53 via RPL5, inducing cell senescence. | None |
| study elucidates a novel correlation between the tumor suppressor gene p53 and the oncogene Ras in regulating EMT program, and expands the knowledge about the function of p53 in EMT process | None |
| The cooperativity- reducing mutation p53E177R in the mouse germline explores the in vivo relevance of DNA binding cooperativity for tumor suppression. | None |
| Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53-Tfam-mitochondrial DNA complex in skeletal muscle. | None |
| although p53 is usually regarded as a tumor suppressor, its constant activation can promote pro-tumorigenic inflammation, at least in part, via inducing HMGB1 release | None |
| the cooperative effect of inactivation of both pRB and p53 tumor suppressor pathways promotes Whole chromosome instability | None |
| mitochondrial p53 may be an important regulator of normal mitochondrial and cellular physiology, potentially exerting tumor suppression activity inside mitochondria. | None |
| p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation. | None |
| Studies indicate that tumor suppressor gene p53 and other genes associated with DNA repair, cell proliferation, migration and angiogenesis are critical for the development of pterygium. | None |
| Data indicate glycogen synthase kinase 3-mediated regulation of MYCN mRNA levels through p53 tumor suppressor protein. | None |
| genetic activation of beta cell glucokinase, initially triggering replication, causes apoptosis associated with DNA double-strand breaks and activation of the tumor suppressor p53. | None |
| we discovered a new MDM2 interacting protein, DNAJB1, and provided evidence to support its p53-dependent tumor suppressor function. | None |
| of mTORC1 signaling to 4E-BP1 requires the coordinated activity of two tumor suppressors, p53 and p63. In contrast, suppression of S6K1 and ribosomal protein S6 phosphorylation by DNA damage is Akt-dependent. | None |
| Studies indicate that the frequent loss of wild-type tumor suppressor p53 function and the gain-of-function of mutant p53 in tumors make p53 an extremely attractive target for cancer therapy. | None |
| Ser46-phosphorylated p53 orchestrates tumor suppressive microRNA expression in the apoptotic response to DNA damage. | None |
| The p53 protein is the most frequently mutated tumor suppressor in cancer, responsible for a range of critical cellular functions that are compromised by the presence of a mutation. | None |
| mTOR activity was markedly increased in p53-deficient tumors and rapamycin treatment suppressed tumor cell growth, identifying mTOR inhibition as a critical p53 tumor suppressive function | None |
| Perturbations of ribosome biogenesis can trigger a p53-dependent checkpoint signaling pathway independent of DNA damage and the tumor suppressor ARF through inhibitory interactions of specific ribosomal components with the p53 negative regulator, Mdm2 | None |
| hTOP3alpha interacts with p53, regulates p53 and p21 expression, and contributes to the p53-mediated tumor suppression | None |
| we have elucidated for the first time in vivo an essential role for endogenous c-Myc in signalling DNA damage-induced apoptosis through the control of the p53 tumour suppressor protein. | None |