| Polymorphism in the tumor suppressor p53 is associated with mycosis fungoides. | None |
| Findings indicate molecular simulations of c-mdm2 proto-oncogene protein (MDM2) and its complex with tumor suppressor protein p53 (p53) by explicit-solvent simulations. | None |
| The integration of multiple omics methods allowed the comprehensive identification of direct and indirect effectors of p53 that provide new insights and leads into the mechanisms of p53-mediated tumor suppression | None |
| Loss of Stat3 signalling disrupts the ARF-Mdm2-p53 tumour suppressor axis bypassing senescence. | None |
| Potential compensatory indels were identified in two tumor suppressor genes, TP53 and PTEN, where compensatory indels are composed of frameshift indels that can recover the original reading frame. | None |
| the tumor suppressor p53 and its signaling are involved in neuronal activity homeostasis | None |
| P53, a multifunctional tumor suppressor, regulated apoptosis in OVCAR-3 cells through a Bcl-2 family protein-dependent pathway | None |
| We have for the first time demonstrated that the tumor suppressor protein, p53, is a regulator of the CYP2A6 gene. | None |
| Data suggest that various pathogenic bacteria/viruses actively inhibit major tumor suppression pathway mediated by TP53 that plays key role in regulation of multiple cellular stress responses/innate immunity and prevention of carcinogenesis. [REVIEW] | None |
| Data indicate that a significant correlation between rab GTP-binding protein (RAB27B) and p53 tumor suppressor protein (p53) expression was observed. | None |
| Data show that proto-oncogene protein Mdm2 inactivation successfully protects tumor suppressor protein (p53)-proficient cells against the cytotoxic effects of Wee1 protein inhibition. | None |
| the role of the tetramerization (oligomerization), which is modulated by the protein concentration of p53, posttranslational modifications, and/or interactions with its binding proteins, in regulating the tumor suppressor function of p53. | None |
| study of inhibition of urothelial tumors with mutations of the tumor suppressor protein TP53 and dysregulation of mTOR signaling | None |
| These data from ATp53 mutations collectively demonstrate that p53_s apoptosis proficiency is dispensable for tumor suppression, but could prognosticate better survival | None |
| Work identifies the TP53 tumor suppressor as a novel target through which NPM1-RARA impacts leukemogenesis. | None |
| Given the critical tumor suppressor role of p53, SETD1A-mediated suppression of this pathway (even in the absence of p53 mutations), would be predicted to have profound consequences on tumorigenesis. | None |
| results imply that the selective advantage produced by human chromosome 17p deletion reflects the combined impact of TP53 loss and the reduced dosage of linked tumour suppressor genes | None |
| particular p53 pathway genes are highly sensitive to heritable and somatic genetic variants, resulting in altered tumour suppression in many tissue types.[review] | None |
| Elevation of the tumour suppressor p53 is necessary and sufficient for crowding hypersensitivity in MDCK cell. | None |
| The inhibition of Wip1 might fortify p53-mediated tumor suppression by Mdm2 antagonists. | None |