| These findings define a hitherto novel mechanism of action for Sam68 in governing p53 transcriptional activation, and represent the first report of Sam68 in the regulation of tumor suppressor activities. | None |
| analysis of the endogenous miR-34A-p53 tumor suppressor network | None |
| Findings indicate the function of tumor suppressor protein p53 (p53) and DNA polymerase iota (POLiota) in the DNA damage response to endogenous or exogenous replication stress. | None |
| findings document contrasting effects of ATM-Mdm2 signaling on p53 tumor suppression and reveal that destabilizing Mdm2 by promoting its phosphorylation by ATM would be effective in treating oncogene-induced malignancies. | None |
| Data indicate that cadmium exposure decreased tumor suppressor protein p53 (p53) level, and induced heme oxygenase-1 (HO-1), apoptosis, and autophagy. | None |
| we found p53 to play a crucial role as a Smad partner in TGF-beta-mediated tumor suppression, and the functional switching of TGF-beta is partially caused by p53 loss or its mutation during tumor development. | None |
| TP53 is a critical tumor suppressor gene that regulates cell cycle progression, apoptosis, and whose reactivation represents a promising anticancer strategy. (Review) | None |
| Antioxidative fraction of white mulberry (Morus alba) was found to have an apotogenic effect on Ehrlich_s ascites carcinoma cell-induced mice (EAC mice) that correlate with upregulated tumor suppressor protein p53 (p53) and downregulated NF-kappa B (NFkappaB) signaling. | None |
| tumor suppressor p53 functions as an essential antiviral molecule against Japanese encephalitis virus | None |
| c-Abl phosphorylation of Mdm2 has a role in regulation of p53 tumor suppression and bone marrow failure | None |
| this study shows that Mysm1 ablation results in a hyperactivated CD8+ T-cell state accompanied by an increased apoptosis and preferential up-regulation of p53 tumor suppressor protein in CD8+ T cells | None |
| Increased the expression of tumor suppressor genes such as Cdkn2A, Rb1 and p53. | None |
| Studies indicate that nucleolar stress triggers several response pathways to maintain cell homeostasis, either tumor suppressor protein p53 (p53)-dependent or p53-independent. | None |
| These data add to the concept that tp53, while classically a tumor suppressor and cell-cycle regulator, has additional roles in controlling cellular oxidative stress. | None |
| Findings suggest that the tumor suppressor capability of wtp53 is dependent upon functional NMIIA and that the invasive phenotype of high-risk mutp53 is independent of NMIIA. | None |
| Results indicate that the induction of long non-coding RNA NEAT1 expression contributes to the tumor-suppressor function of p53 and suggest that p53 and NEAT1 constitute a transcriptional network contributing to various biological functions and tumor suppression. | None |
| About half of HPV-negative penile cancers are driven by oncogenic activation of TP53, while a quarter is induced by loss of TP53 tumor suppressor function | None |
| structured RNAs prevent p53C aggregation through surface interaction and play a significant role in the regulation of the tumor suppressor protein. | None |
| We could identify no prognostic effect of the KRAS or EGFR driver and TP53 tumor suppressor comutation. | None |
| In this study, we investigate the activities of p53 under normal low-stress conditions and discover that p53 is capable of maintaining the expression of a group of important tumor suppressor genes at baseline, many of which are haploinsufficient, which could contribute to p53-mediated tumor suppression | None |