| In transfected cells and KSHV-infected B lymphoma cells, KSHV-encoded latency-associated nuclear antigen (LANA) expression stimulates degradation of tumor suppressors von Hippel-Lindau and p53. | lymphoma, |
| high and low P-glycoprotein, glutathione S-transferase pi expression, excision repair cross-complementing 1 alterations, and tumor suppressor p53 mutation were candidates for future clinical trials of chemosensitivity tests in lung cancer patients. | lung, |
| data suggest that this tumor suppressor gene plays a critical role in the multistep carcinogenesis process for esophageal squamous cell cancer | esophageal, |
| RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC. | retinoblastoma, |
| Expression of both MDM2 and MDM4 in tumors without p53 mutations strongly suggests that MDM2 and MDM4 inhibit the activity of this tumor suppressor in head and neck squamous carcinomas. | HNSC, |
| Loss of heterozygosity (LOH) of the hDMP1 gene was detectable in approximately 35% of human lung carcinomas, which was found in mutually exclusive fashion with LOH of INK4a/ARF or that of P53. DMP1 is a pivotal tumor suppressor for human lung cancers. | lung, |
| Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma | lymphoma, |
| Polymorphism Arg72Pro in tumor suppressor gene TP53 increases the risk of lung cancer, especially for small cell lung cancer and heavy smokers. | lung, |
| Skin cells grown in culture showed a notable decrease in the UVB fingerprint mutation on the p53 tumor suppressor gene in fibroblasts during proliferation. | skin, |
| data suggest that UVB-induced, stress-induced premature senescence in skin fibroblasts plays an important role in p53-related apoptosis resistance and tumor suppression activity | skin, |
| The existence of a functional binding site for the tumor suppressor p53 near the proximal CCAAT box and the fact that the basal expression of annexin A1 in human colon adenocarcinoma cells is driven by p53 at the transcriptional level, is shown. | colorectal, |
| evaluated the expression of the tumour suppressors p14, p16 and p53 in pre-malignant and malignant squamous skin tumours, and its relation with risk factors for skin carcinogenesis (HPV, immune status and sun exposure). | skin, |
| Myc-driven lymphomagenesis p73 has weak tumor suppressor activity compared with p53 | lymphoma, |
| Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. | astrocytomas, |
| Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer. | prostate, |
| Results suggest that simultaneous exposure to ACR and long-term dietary corn oil induces development of colon cancer partly by inhibiting the tumor suppressor gene p53-mediated mitochondria-dependent apoptosis. | colorectal, |
| XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway. | colorectal, |
| Mdmx downregulation is crucial for effective p53-mediated radiation responses and tumor suppression in vivo in a mouse model of B cell lymphoma. | lymphoma, |
| TP53 tumour suppressor gene mutations have a role in development of smoking-related bulky DNA adducts in a lung cancer study population from Hungary | lung, |
| miR-34 may restore, at least in part, the tumor suppressing function of the p53 in p53-deficient human pancreatic cancer cells | pancreatic, |