| Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors. | testicular, |
| p53 tumor suppressor activity loss may have a role in negative prognosis of mantle cell lymphoma | lymphoma, |
| Results demonstrate that miR-34a acts as a tumor suppressor in p53-mutant glioma cells U251, partially through regulating SIRT1. | glioma, |
| Simultaneous deletion of Brca2 and the tumour suppressor Trp53 in prostate epithelia gave rise to focal hyperplasia and atypical cells | prostate, |
| marker for malignant melanoma, S100B, likely contributes to cancer progression by down-regulating the tumor suppressor protein, p53. | skin, |
| MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein | kidney, |
| study demonstrates that intermittently sun-exposed skin contains an extensive number of phenotypically intact cell compartments bearing missense and nonsense mutations in the p53 tumor suppressor gene | skin, |
| Somatic inactivating mutations of the tumor suppressor gene TP53 is associated with a group of aggressive adrenocortical cancers. | adrenocortical, |
| Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor. | pancreatic, |
| Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer. | colorectal, |
| In melanomas expressing high levels of wild type p53 this tumor suppressor is frequently inactivated at transcriptional level. | skin, |
| ZNF668 was identified as a novel breast tumor suppressor protein that regeulates the stability p53 tumor suppression proteins. | breast, |
| Inactivation of fumarate hydratase drives a metabolic shift to aerobic glycolysis in FH-de fi cient kidney tumors resulting in decre ased levels of p53 tumor suppressor. | kidney, |
| There is a functional link between S100A14 and the tumor suppressor protein p53 in oral squamous cell carcinoma cell lines | oral |
| These findings expose another facet of p53 functions unrelated to tumor suppression and render it a novel regulator of hepatic lipid metabolism and consequently of systemic lipid homeostasis and atherosclerosis development. | liver, |
| It was concluded that posttranslational modifications of tumor suppressor protein p53 are important determinants of p53 stability and physiological functions in the developing kidney. | kidney, |
| Five percent of women with uterine serous carcinoma have germline mutations the tumor suppressor genes BRCA1, CHEK2, and TP53. | uterine, |
| this study was focused on aberrations of the tumor suppressor genes TP53 and PTEN in cancer stromal fibroblasts of breast cancer. | breast, |
| although p53 is usually regarded as a tumor suppressor, its constant activation can promote pro-tumorigenic inflammation, especially in livers exposed to agents that inflict lasting mutagenic DNA damage. | liver, |
| data indicate p53(72Arg) variant appears to be a more potent in vivo transcription factor and tumor suppressor in breast cancer than the p53(72Pro) variant; the Arg72Pro genotype has no significant effects in patients with TP53 mutated tumors in which p53 is non-functional | breast, |