| The tumor suppressor, p53, contributes to radiosensitivity of lung cancer cells by regulating autophagy and apoptosis. | lung, |
| The tumor suppressor p53 plays a role in regulating nuclear GSK-3 levels and Wnt signaling through the non-coding UTR of Axin2 in colorectal cancer. | colorectal, |
| Data from knockout mice suggest that ghrelin requires p53 (tumor suppressor protein p53) for its action in liver and white adipose tissue in induction of lipogenic and adipogenic enzymes that leads ultimately to increase in body weight/adiposity. | liver, |
| Data suggest that the opposing effect on survival of retinoblastoma tumor suppressor protein (Rb)-deficient alpha- and beta-cells was a result of opposing effects on p53 in these cell types. | retinoblastoma, |
| Results suggest that decreased expression of AKR1B10 could disrupt the tumor suppressive function of p53, which result in decreased survival in colorectal cancer patients. | colorectal, |
| CYP2E1 exerts an important role in mammary carcinogenesis, provide a potential link between ethanol metabolism and breast cancer.Induction of CYP2E1 gene expression is under the transcriptional control of the p53 tumor suppressor. | breast, |
| in a humanized genetically-modified mouse model of pancreatic ductal adenocarcinoma (PDAC), that autophagy_s role in tumour development is intrinsically connected to the status of the tumour suppressor p53 | pancreatic, |
| impact of SIRT1 on melanoma tumor cell growth and survival through the tumor suppressor p53 and its downstream effector p21 | skin, |
| Using human glioblastoma multiforma cell lines, this research team demonstrated that the delivery of exogenous wild-type tumor suppressor gene p53 via a tumor-targeted nanocomplex limited the development of temozolomide resistance | liver,glioblastoma, |
| Studies suggest that positive/high tumor suppressor protein p53 expression may be a useful biomarker to predict a poorer prognosis for patients with gastric cancer. | gastric, |
| Loss of p53 tumor suppressor function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease. | breast, |
| Data suggest that trans-splicing would be developed as a therapeutic approach for colorectal cancers carrying tumor suppressor protein p53 (p53) mutation. | colorectal, |
| Results imply CST5 as an important mediator of tumor suppression by p53 in colorectal cancer. | colorectal, |
| Loss of p53 tumor suppressor function through progressive steps may be directly involved in skin carcinogenesis | skin, |
| Data suggest that microRBA mir-886 (VTRNA2-1-5p) is a direct regulator of tumor suppressor protein p53 (p53) and suggest that it plays an essential role in the apoptosis and proliferation of cervical cancer cells. | cervical, |
| Data suggest that targeting BNIP3L protein in wild-type p53 tumor suppressor colon cancer cells is an anticancer strategy activating iron depletion signaling and the mitophagy-related cell death pathway. | colorectal, |
| LATS1 and LATS2 are frequently down-regulated in breast cancer; we propose that such down-regulation might benefit cancer by converting p53 from a tumor suppressor into a tumor facilitator | breast, |
| Data show that off the 81 BRCA-negative patients, 3 exonic mutations in the tumor suppressor protein p53 (TP53) gene were identified in 3 breast cancer patients. | breast, |
| Bmal1 could directly bind to the p53 gene promoter and thereby transcriptionally activate the downstream tumor suppressor pathway in a p53-dependent manner in pancreatic tumors. | pancreatic, |
| Data show that combined deletion of X-ray repair cross-complementing protein 4 (Xrcc4) and tumor suppressor p53 (Trp53) predisposes B cells to lymphomagenesis. | lymphoma, |