| Ablation of E6 by siRNA induces the tumor suppressor p53 and diminishes beta-defensin-3 (hBD3) in HPV-16 positive CaSki cervical cancer cells and UM-SCC-104 head and neck cancer cells. | cervical,HNSC, |
| Cytokeratin-19 (CK-19)+ specific deletion of tumor suppressors p53 and Retinoblastoma (Rb) indicated that carcinomas at the injury site originates from cholangiocytes or liver progenitor cells. | liver,retinoblastoma, |
| The upregulation of the tumor suppressor protein p53 was linked to p53 gene mutations in hepatocellular carcinoma. (Meta-analysis) | liver, |
| HDAC9 might contribute to lymphomagenesis by altering pathways involved in growth and survival, as well as modulating BCL6 activity and p53 tumor suppressor function. | lymphoma, |
| Delta40p53alpha acts as an important tumor suppressor in hepatocellular carcinoma cells. | liver, |
| Data suggest that tumor suppressor protein p53 has a limited contribution to the development of injury in the immature/juvenile brain following hypoxia-ischemia (HI). | brain, |
| p53 tumor suppressor pathway was downregulated as demonstrated by both aCGH and RNA-seq analysis. Notch, EGFR, NRAS, and RB1 pathways were also significantly dysregulated in tumors compared with normal liver tissue | liver, |
| Tumor suppressor p53 protein mutation from lung carcinoma patients stimulates cell spreading and migration. Mutant p53 (R175H) decrease the expression of Rho GTPase activating protein 44 in both mRNA and protein level. | lung, |
| in the absence of the tumor suppressor p53, germline genetic deletion of AMPK beta1 accelerates the appearance of a T-cell lymphoma that reduces lifespan compared to p53 deficiency alone. | lymphoma, |
| Mutations in both the p53 tumor suppressor gene and K-ras oncogene are highly frequent in lung tumors from nonsmoking women in China. The predominance of G-->T transversions in both genes and the occurrence of p53 mutations within a specific GC rich region or at specific hotspot codons on the non-transcribed strand are consistent with exposure to smoky coal emissions. | lung, |
| USP12 deubiquitinates MDM2 and AR, which in turn controls the levels of the TP53 tumour suppressor and AR oncogene in prostate cancer. | prostate, |
| In lung cancer cells, TREM2 gene is regulated by p53 tumor suppressor protein. | lung, |
| our findings successfully demonstrate for the first time that LACTB is a novel epigenetic silenced tumor suppressor through modulating the stability of p53, supporting the pursuit of LACTB as a potential therapeutic target for colorectal cancer | colorectal, |
| Study revealed that the Wnt/beta-catenin signaling pathway and its major downstream target, c-Myc increased the miR552 levels and miR552 directly targets p53 tumor suppressor. miR552 may serve as an important link between functional loss of APC, leading to abnormal Wnt signals, and the absence of p53 protein in colorectal cancer. | colorectal, |
| In patients with oropharyngeal squamous cell carcinoma (OPSCC), combined bcl-2-like protein 1 apoptosis regulator (Bcl-xL) and tumor suppressor Protein p53 expression has a survival benefit in a select population of non-smokers with cyclin-dependent kinase inhibitor p16 positive disease. There is no statistically significant association between p53 expression and nodal disease, overall survival, and disease-free survival. | laryngeal, |
| Copy number variations of TP53 tumour suppressor gene associated with altered phosphorylation status of p53 protein is associated with sporadic schwannomas. | schwannomas, |
| We assessed the genomic landscape of canine hemangiosarcoma via whole-exome sequencing (47 golden retriever hemangiosarcomas) and RNA sequencing (74 hemangiosarcomas from multiple breeds). Somatic coding mutations occurred most frequently in the tumor suppressor TP53 (59.6% of cases) as well as two genes in the PI3K pathway: the oncogene PIK3CA (29.8%) and its regulatory subunit PIK3R1 (8.5%). | sarcoma, |
| Mutation in the tumor suppressor gene TP53 can be detected in the CSF of patients with lung cancer associated meningitis. Patients with such mutation have earlier meningeal metastasis and shorter median survival time | lung, |
| Allelic loss analysis of gamma-ray-induced mouse thymic lymphomas: two candidate tumor suppressor gene loci on chromosomes 12 and 16. | lymphoma, |
| Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity | None |