Sentence and cancer type
Showing 101-120 of 386 items.
SentenceCancertype
Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin ANone
Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A.None
Human tumor suppressor ARF impedes S-phase progression independent of p53.None
NO induces the accumulation of transcriptionally active p53 in a variety of cell types and NO signaling to p53 does not require ataxia telangiectasia-mutated (ATM), poly(ADP-ribose) polymerase 1, or the ARF tumor suppressor proteinNone
Refolding and structural characterization of the human p53 tumor suppressor protein.None
Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277.None
Characterization of the promoter region of UPase has indicated a direct regulation of its expression by the tumor suppressor gene p53. Review.None
Data suggest a model in which p53 directly recruits a TRRAP/acetyltransferase complex to the mdm2 gene to activate transcription. In addition, this study defines a novel mechanism utilized by the p53 tumor suppressor to regulate gene expression.None
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.None
The suppression of STK15 oncogenic activity by p53 might be explained by the finding that p53 inhibited STK15 kinase activity via direct interaction with the latter_s Aurora box. This revealed a novel mechanism for the tumor suppressor function of p53.None
The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2.None
Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressorNone
azurin, tumor suppressor protein p53, and regression of cancerNone
IRF-1 and the tumour suppressor protein p53 are coordinately up-regulated during the response to DNA damage in an ATM-dependent manner.None
investigated whether Tat might alter p53 acetylation and p53-responsive transcription; results allude to mechanism where the HIV-1 trans-activator might impair tumor suppressor functions favoring establishment of neoplasia in AIDSNone
The complement inhibitor CD59 and the lymphocyte function-associated antigen-3 (LFA-3, CD58) genes possess functional binding sites for the p53 tumor suppressor protein.None
cyclin G1 has growth inhibitory activity that is mechanistically linked to ARF-p53 and pRb tumor suppressor pathways.None
Methylation of CpG and CCWGG motifs in the promoter of TP53 could represent a novel mechanism leading to functional impairment of this tumor suppressor gene in ALL.None
EGR1 as a major regulator of cell senescence and previously undescribed upstream gatekeeper of the p53 tumor suppressor pathway.None
deacetylase HDAC1 acts as an antagonist of the tumor suppressor p53 in the regulation of the cyclin-dependent kinase inhibitor p21None