| observations indicate that p53 tumor suppressor , acting through suppression of nuclear factor kappa B, plays the role of a general buffer of innate immune response in vivo | None |
| INK4a/ARF: a multifunctional tumor suppressor locus. | None |
| Ca2+ binding of human p53 tumor suppressor target peptide (residues 367-388) to rat S100B decreases the Ca2+ dissociation rate by approximately an order of magnitude. | None |
| data indicate that attenuation rather than complete inactivation of Rb tumor suppressor gene function, in the context of p53 inhibition, is sufficient to initiate tumorigenesis in this model of islet cell cancer | None |
| results demonstrate the relevance of cellular senescence in restricting tumorigenesis in vivo and support a model for cooperative tumour suppression in which p53 is an essential failsafe protein of Pten-deficient tumours | None |
| Inactivation of p53 and a conditional allele of the NF1 tumor suppressor that negatively regulates Ras signaling induce malignant astrocytoma. | None |
| vascular smooth muscle cell apoptosis proceeds through a pathway that involves PKCdelta, the intermediary p38 MAPK, and the downstream target tumor suppressor p53 | None |
| Tumor suppressor molecule p53 maintains mitochondrial genetic stability through its ability to translocate to mitochondria and interact with mtDNA polymerase gamma (pol gamma) in response to mtDNA damage. | None |
| Increased protein-levels of PPM1D may link the TP53 and RB1 tumor suppressor pathways to medulloblastoma pathomechanisms. | None |
| p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation. | None |
| Tumor suppressor p53 structure was determined in solution using state-of-the-art isotopic labeling techniques and NMR spectroscopy to complement its crystal structure. | None |
| results indicate that KSHV vIRF1 comprehensively compromises an ATM/p53-mediated DNA damage response checkpoint by targeting both upstream ATM kinase and downstream p53 tumor suppressor | None |
| The CDK inhibitor p18Ink4c is a tumor suppressor in medulloblastoma. | None |
| IRF3 induces cell growth inhibition and cellular senescence through activation of p53 tumor suppressor | None |
| Genetic mapping of a putative tumor suppressor locus that influences tumorigenesis and metastasis in mice. | None |
| Mdm4 regulates tumor suppressor p53 activity, while Mdm2 mainly controls p53 stability | None |
| selected examples of tumor suppressors, including BRCA1, p53, and WT1, whose mechanism of action involves regulation of IGF-IR gene expression. [REVIEW] | None |
| These results suggest that the tumor suppressor pVHL has an unexpected function to upregulate the tumor suppressor p53. | None |
| In mammalian cells, translesion DNA synthesis (TLS) is controlled by the tumor suppressor p53, and by the cell cycle inhibitor p21 via its PCNA-interacting domain, to maintain a low mutagenic load at the price of reduced repair efficiency. | None |
| ASPP2 is a haploinsufficient tumor suppressor that shares overlapping function(s) with p53 in mouse development and tumor suppression. | None |