| GAS41 plays a role in repressing the p53 tumor suppressor pathway during the normal cell cycle by a TIP60-independent mechanism. | None |
| measured the dynamics of the negative feedback loop between the tumor suppressor p53 and the oncogene Mdm2 | None |
| genomic instability is an early event that occurs at precancerous stages prior to changes in tumor suppressor genes (p53 and adenomatosis polyposis coli) in Barrett_s esophagus-associated tumorigenesis in patients | None |
| In the complex crystal structure of p53 tumor suppressor bound to large T-antigen (LTag) oncoprotein, p53 inhibits LTag helicase function through direct complex formation. | None |
| distinct single nucleotide changes in the BRCT domain of BRCA1 affect binding of this protein to the tumor suppressor p53 | None |
| Nf1 expression is dependent on strain background: implications for tumor suppressor haploinsufficiency studies. | None |
| Review of ongoing work on biological functions of p53 tumor suppressor in different cell types and under various physiological conditions will help to unravel the complexity of molecular circuits that orchestrate the biological response to p53 activation. | None |
| The evolutionary perspective in this review indicates that p53 evolved so as to play a subtle but very important role during development, and suggests that p53 was primarily selected for its developmental role and not as a tumor suppressor gene. | None |
| The evolutionary perspective in this review indicates that p53 evolved to play a subtle but important role during development, while its role as a tumor suppressor is only important in animals that are protected from most sources of extrinsic mortality. | None |
| Eight of the nine samples showed a loss of 17pter-->p13, the locus of tumor suppressor TP53 preceding the amplified area 17p12-->p11.2. | None |
| inactivation of Cdh1 and Cdh5 is likely to cooperate with the loss of p53, suggesting a possible tumor suppressive function of these genes in mammary carcinogenesis | None |
| Data demonstrate a novel link between p53 and Notch1 in keratinocyte differentiation upon genotoxic stress and suggest a novel tumor suppressor mechanism of p53 in the development of HPV-induced tumors. | None |
| the binding of nuclear p53 to the specific sites within the PUMA promoter is essential for its ability to induce apoptosis and is likely to be required for its tumor suppressive capacity | None |
| Tumor suppressor p53 Arg72Pro polymorphism leads to increased longevity, but not to decreased risk of cancer. | None |
| phosphorylation of Pirh2 may act as a fine-tuning to maintain the balance of p53-Pirh2 autoregulatory feedback loop, which facilitates the tight regulation of p53 stability and tumor suppression | None |
| MEG3 non-coding RNA may function as a tumor suppressor, whose action is mediated by both p53-dependent and p53-independent pathways | None |
| p53 and Msh6 are functionally interrelated and these tumor suppressors act together to accelerate tumorigenesis. | None |
| Results suggest that the cross talk between lysine methylation and acetylation is critical for p53 activation in response to DNA damage and that Set7/9 may play an important role in tumor suppression. | None |
| BARD1 may regulate the transcriptional activities of p53 as tumor suppressors | None |
| The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. | None |