| 53BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-kappaB through miR-146a. | breast, |
| crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor | None |
| 53BP1 acts downstream of ATM and upstream of Chk2 in the DNA damage response pathway and is involved in tumor suppression | None |
| MDC1 functions as an upstream regulator of 53BP1 in the DDR pathway and in tumor suppression | None |
| study uncovers novel ATM-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection | None |
| 53BP1 functioned as a tumor suppressor gene by its novel negative control of Epithelial-mesenchymal transition through regulating the expression of miR-200b/429 and their target gene ZEB1. | None |