| p73 isoforms affect the retinoblastoma protein (RB) tumor suppressor pathway independent of p53 | retinoblastoma, |
| p73 tumor-suppressor activity is impaired in human thyroid cancer. | thyroid, |
| p73 plays a tumor suppressor role in bladder cancer, and its inactivation occurs through an epigenetic mechanism, most probably involving protein degradation. | bladder, |
| p73 might play some role in tumor progression of HCC even though p73 should not be considered a candidate gene on chromosome 1p of hepatocellular carcinoma and does not function as a tumor suppressor gene like p53 | liver, |
| Myc-driven lymphomagenesis p73 has weak tumor suppressor activity compared with p53 | lymphoma, |
| The existence of a proapoptotic autoregulatory feedback loop between p73, YAP, and the promyelocytic leukemia (PML) tumor suppressor gene, is shown. | leukemia, |
| Results suggest that p73 may serve as a tumor suppressor gene and its expression plays a role in tumorigenesis in Japanese patients with breast cancer. | breast, |
| Studies suggest that tumor suppressor protein p73 G4C14-to-A4T14 polymorphism may play a major role in susceptibility to lung cancer in Caucasians. | lung, |
| CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer. | HNSC, |
| P73 tumor suppressor and its targets, p21 and PUMA, are required for madin-darby canine kidney cell morphogenesis by maintaining an appropriate level of epithelial to mesenchymal transition | kidney, |
| The p73 gene may play a role as a tumor suppressor in the colorectal cancer progression. | colorectal, |
| Using human and murine in vitro systems, in vivo xenograft modeling as well as patient-derived brain tumor initiating cells, study demonstrates that tumor suppressor TAp73 is required for maintaining the growth and stemness features of stem-like cancer cells. TAp73 modifies the proline regulatory axis through regulation of enzymes GLS, OAT, and PYCR1 involved in the interconversion of proline-glutamine-ornithine. | brain, |
| Allelic expression of the putative tumor suppressor gene p73 in human fetal tissues and tumor specimens. | None |
| transcriptional activation function of p73 is specifically targeted by E1A through a mechanism involving p300/CBP proteins during the process of transformation and that p73 may have a role to play as a tumor suppressor | None |
| functional cross-talk between p73 and Wwox tumor suppressor protein | None |
| Emerging evidence in this review discusses a key survival/death checkpoint in both peripheral and central neurons that involves the p53 tumor suppressor and its newly discovered family members, p73 and p63. | None |
| p73, through HDM2, can oppose p53 tumor suppressor function and possibly contribute to tumorigenesis | None |
| RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. | None |
| Fosters tumor suppression through enhancement of the DNA-binding activity of p63gamma isoforms and through inhibition of transcriptional repressors Mdm2 or DeltaNp63alpha. | None |
| p73 can function as a tumour suppressor independent of its family member p53 and the its TAp73 isoform is a barrier to anchorage-independent growth | None |