| Human bladder tumors with 2-hit mutations of tumor suppressor gene TSC1 and decreased expression of p27. | bladder, |
| Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2. | myoma, |
| Tuberous sclerosis complex 1: an epithelial tumor suppressor essential to prevent spontaneous prostate cancer in aged mice. | prostate, |
| Loss of the tumor suppressor tuberous sclerosis complex 1 (Tsc1) in the liver promotes gluconeogenesis and glucose intolerance. | liver, |
| Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. | None |
| The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton. | None |
| Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38. | None |
| The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. | None |
| Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. | None |
| Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. | None |
| Tuberous sclerosis tumor suppressors TSC1 and TSC2 form a protein complex that integrates and transmits cellular growth factor and stress signals to negatively regulate checkpoint kinase TOR activity, as described in this review. | None |
| According to Knudson_s two-hit model of tumorigenesis, second-hit mutation and resulting loss of heterozygosity of a tumor suppressor gene (tsc1 and tsc2) is necessary for tumor formation | None |
| WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. | None |
| our data suggest that hamartin, which has mainly been regarded as an interaction partner in the tumor suppressor complex (TSC) with tuberin, has a pronounced independent functional relevance in the pathogenetic context of TSC and cortical dysplasias | None |
| Inhibition of mTORC1, pathologically activated by loss of the TSC1/TSC2 tumor suppressor complex, by sirolimus is a rational mechanistic target for therapy in PEComas. | None |
| FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. | None |
| The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin. | None |
| The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. | None |
| Loss of the tuberous sclerosis complex (TSC) tumor suppressors results in activation of mTORC1 and development of the tumor syndrome tuberous sclerosis complex (TSC). | None |
| Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients | None |