| The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. | None |
| The LKB1 tumor suppressor negatively regulates mTOR signaling. | None |
| Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. | None |
| Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. | None |
| Tuberous sclerosis tumor suppressors TSC1 and TSC2 form a protein complex that integrates and transmits cellular growth factor and stress signals to negatively regulate checkpoint kinase TOR activity, as described in this review. | None |
| According to Knudson_s two-hit model of tumorigenesis, second-hit mutation and resulting loss of heterozygosity of a tumor suppressor gene (tsc1 and tsc2) is necessary for tumor formation | None |
| p27 localization during the mammalian cell cycle is under the control of the tumor suppressor tuberin | None |
| This is the first description of a functional interaction between the tumor suppressor tuberin and the oncogene Ras in regulating apoptosis. | None |
| WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. | None |
| Inhibition of mTORC1, pathologically activated by loss of the TSC1/TSC2 tumor suppressor complex, by sirolimus is a rational mechanistic target for therapy in PEComas. | None |
| The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin. | None |
| The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1. | None |
| study found tuberin and PRAS40 to be potent anti-apoptotic gatekeepers in early mammalian stem-cell differentiation; data allow new insights into the regulation of early stem-cell maintenance and differentiation and identify a new role of the tumor suppressor tuberin and the oncogenic protein PRAS40 | None |
| study found tuberin and PRAS40 to be potent anti-apoptotic gatekeepers in early stem-cell differentiation; data allow new insights into the regulation of early stem-cell maintenance and differentiation and identify a new role of the tumor suppressor tuberin and the oncogenic protein PRAS40 | None |
| study demonstrates that in the Drosophila lymph gland the tumor suppressors TSC and PTEN control blood progenitor proliferation through a common TOR- and 4EBP-dependent pathway | None |
| Loss of the tuberous sclerosis complex (TSC) tumor suppressors results in activation of mTORC1 and development of the tumor syndrome tuberous sclerosis complex (TSC). | None |
| Here we report that loss of the tumor suppressor gene Tsc2 in pericytes using a FoxD1 promoter driven cre allele (Foxd1tm1(GFP/cre) Amc, FoxD1GC) leads to the formation of Hemangiopericytoma in multiple sites | None |