| Results demonstrate that aberrant expression of USP4 contributes to the development and progression of colorectal cancer and reveal a critical mechanism underlying USP4-mediated oncogenic activity. | colorectal, |
| cyclophilin A (CypA) was identified as an important molecule for USP4-mediated oncogenic activity in hepatocellular carcinoma. | liver, |
| the up-regulated USP4 plays an oncogenic role in melanoma by simultaneously suppressing stress-induced cell apoptosis and facilitating tumour metastasis. | skin, |
| Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors. | lung, |
| Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. | None |
| Characterization of the ubiquitin-specific protease activity of the mouse/human Unp/Unph oncoprotein. | None |
| Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme. | None |
| the existence of a nuclear export signal ((133)VEVYLLELKL(142)) in Usp4;Usp4 is thus the first oncogenic deubiquitylating enzyme reported to have nucleocytoplasmic shuttling properties. | None |
| Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity. | None |
| The Unp proto-oncogene encodes a nuclear protein. | None |