Sentence and cancer type
Showing 1-14 of 14 items.
SentenceCancertype
Wnt-5a serves as an antagonist to the canonical Wnt-signaling pathway with tumor suppressor activity in differentiated thyroid carcinomas.thyroid,
WNT5A, a putative tumor suppressor gene in acute myeloid leukemia (AML), is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression.leukemia,
finding together with our in vitro data demonstrating the ability of Wnt5a to impair the invasive properties of prostate cancer cells, suggests a tumor suppressing effect of Wnt5a in localized prostate cancerprostate,
Data suggest that Wnt5a and Ror2 may serve as tumor suppressor genes in the development of hepatocellular carcinoma, and may serve as clinicopathologic biomarkers for prognosis in HCC patients.liver,
Our findings indicate that Wnt5a might act as tumor suppressor by inhibiting cell proliferation and attenuating EMT in colon cancer cellscolorectal,
WIF-1 is frequently methylated and that Wnt5a acts as a tumor suppressor gene in colorectal carcinoma.colorectal,
Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue.None
WNT5A, a putative tumour suppressor gene in ALL, is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression and confers poor prognosis in patients with ALL.None
Results suggest that Wnt5a plays the role of a tumor suppressor in leukemogenesis through the Wnt5a/Ror2 noncanonical signaling pathway that inhibits Wnt canonical signaling.None
5-FU-induced tumor suppression (reduced cell viability) was reduced by WNT5A overexpression in hypermethylated HCT116 and SW620 cells and enhanced by WNT5A downregulation in unmethylated LoVo and SW480 cells.None
Oncogenic effects of WNT5A in Epstein-Barr virusassociated nasopharyngeal carcinoma. nasopharyngeal,laryngeal,
Findings suggest that high receptor tyrosine kinase-like orphan receptor (ROR) 2 or proto-oncogene protein Wnt-5A (Wnt5a) expression is associated with poor prognosis in non-small cell lung cancer (NSCLC).lung,
Study established a glioblastoma model that affords a direct comparison of genome-wide histone modifications and associated gene expression alterations between parental human neural stem cells and their derivative oncogene-induced glioblastoma stem cells (iGSCs), identifying PAX6- and DLX5-regulated WNT5A as a key factor driving iGSCs differentiation into GSC differentiation into endothelial-like cells (GdECs).glioblastoma,
Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. None