| Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. Overexpression of the three most frequently down-regulated candidates, SLC5A8, IRX1, and EBF3, validated their tumor suppressor potential by growth curve analysis and colony formation assay. | colorectal,HNSC, |
| Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma. | gastric, |
| Multiple evidences suggested that PRMT5 repressed transcription of tumor suppressor IRX1 via recruitment of DNMT3A on promoter. | None |
| Iroquois Homeobox 1 Acts as a True Tumor Suppressor in Multiple Organs by Regulating Cell Cycle Progression | None |