| Our results demonstrate that the majority of RARA-negative acute promyelocytic leukemia (APL) have RARB translocations, thereby forming a novel, distinct subgroup of APL. TBL1XR1-RARB as an oncogenic protein exerts effects similar to those of PML-RARA, underpinning the importance of retinoic acid pathway alterations in the pathogenesis of APL. | leukemia, |