| TET1 exerts its tumor suppressor function by regulating autophagy in glioma. | glioma, |
| MicroRNA-21 promotes cell proliferation by targeting tumor suppressor TET1 in colorectal cancer | colorectal, |
| TET1 is a Tumor Suppressor That Inhibits Papillary Thyroid Carcinoma Cell Migration and Invasion | thyroid, |
| Expression of Concern: TET1 exerts its tumor suppressor function by regulating autophagy in glioma cells | glioma, |
| GABRA3 also carries a microRNA (miR-767) with predicted target sites in TET1 and TET3, two members of the ten-eleven-translocation family of tumor suppressor genes, involved in the conversion of 5-methylcytosines to 5-hydroxymethylcytosines in DNA. | None |
| these findings provide in vivo evidence of a function for TET1 as a tumor suppressor of hematopoietic malignancy. | None |
| Study comprehensively examined TET1 expression and methylation status in multiple tumors, and demonstrated that promoter CpG methylation is a predominant mechanism for TET1 inactivation in human cancers. TET1 as a tumor suppressor and CpG demethylase in tumor cells requires its intact catalytic domain, which provides new insight into the epigenetic master role of TET1 in tumor pathogenesis. | None |
| TET1 plays an essential oncogenic role in MLL-rearranged leukemia. | leukemia, |
| Data indicate that tet oncogene 1 protein (TET1) silencing in primary epithelial colon cells increase their cellular proliferation. | colorectal, |
| Results indicate that tet oncogene 1 protein (Tet1) and tet oncogene 2 protein (Tet2) play a critical role in maintaining bone marrow MSCs (BMMSCs) and bone homeostasis through demethylation of P2X7 purinoceptor (P2rX7) to control exosome and miRNA release. | None |