| RAC3 is an inhibitor of senescence whose downregulation in aged individuals could be probably a tumor suppressor mechanism. | None |
| The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression. | breast, |
| Deregulated E2F and the AAA+ coregulator ANCCA drive proto-oncogene ACTR/AIB1 overexpression in breast cancer. | breast, |
| AIB1 can exert its oncogenicity through tissue-specific estrogen-dependent and estrogen-independent functions leading to breast cancer. | breast, |
| Frequent amplification of AIB1, a critical oncogene modulating major signaling pathways, is associated with poor survival in gastric cancer. | gastric, |
| The oncogenic transcription factor AIB1 has a novel role in the regulation of polyribosome recruitment and formation of the translational complex. Combinatorial therapies targeting IGF signaling and mRNA translation in AIB1 expressing breast cancers may have clinical benefit and warrants further investigation | breast, |
| High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. | None |
| There is a positive feedback regulatory loop consisting of E2F1 and SRC-3 to maintain high levels of SRC-3 and E2F1 activity, which may partially interpret the oncogenic role of SRC-3 overexpression. | None |
| Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. | None |
| Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland. | None |
| Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression. | None |
| Dysregulation of nuclear shuttling and proteasomal degradation may modulate the oncogenic potential of AIB1. | None |
| SRC-3Delta4, a splicing isoform of the SRC-3 oncogene, is a signaling adaptor that links EGFR and FAK and promotes EGF-induced phosphorylations of FAK and c-Src. | None |
| Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. | None |
| The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFkappaB signal transduction. | None |
| PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha. | None |
| FoxG1 can function as a pro-apoptotic factor in part through suppression of AIB1 coactivator transcription complex formation, thereby reducing the expression of the AIB1 oncogene. | None |