| These results reveal an important mode of Myc activation in human breast cancer and a mechanism contributing to Myc deregulation involving unique insight into inactivation of the Axin1 tumor suppressor in breast cancer. | breast, |
| Axin acts as a tumor suppressor by facilitating p53 function | None |
| A novel role for the tumour suppressor scaffold protein Axin1 in facilitating the formation of a degradation complex for c-Myc containing GSK3beta, Pin1, and PP2A-B56alpha is reported. | None |
| Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded. | None |