| BAP1 is an important uveal and cutaneous melanoma tumor suppressor gene. | skin, |
| Both Vhl and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl in the kidney. | kidney, |
| Study shows that the tumor suppressor gene breast cancer [BRCA]1-associated protein 1 (BAP1) is inactivated in 6 high-grade, rhabdoid meningiomas. In addition to patients with somatic BAP1 loss, 2 patients carried germline mutations, indicating that such meningiomas can arise as part of the BAP1 cancer predisposition syndrome. | meningiomas,breast, |
| Our data confirm the established role of BAP1 as a tumor suppressor protein and is the first report where BAP1 has been studied in pT1 clear cell renal cell carcinomas | kidney, |
| BAP1, a tumor suppressor gene driving malignant mesothelioma | mesothelioma, |
| The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma | skin, |
| Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids | liver, |
| The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma | pancreatic, |
| BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. | pancreatic, |
| identification of the deubiquitinating enzyme BAP1 as a tumor suppressor may lead to further understanding of how the ubiquitin proteasome system contributes to cancer and aid in the identification of new targets for cancer therapy | None |
| These results suggest that the lack of the tumor suppressor BAP1 may be more specifically involved in the pathogenesis of epithelioid MM rather than non-epithelioid MM. | None |
| results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; a BAP1 catalytic mutation found in a myelodysplastic syndrome patient implies that BAP1 loss of function has similar consequences in mice and humans | None |
| We detected a cosegregating BAP1 germline mutation in two family members with UM. This suggests that, consistent with a classic tumour suppressor model, carriers of damaging mutations in BAP1 are predisposed to UM. | None |
| BAP1 has an important role in DSB repair by homologous recombination, which is a possible molecular basis for its tumor suppressor function | None |
| identifies a new BAP1 mutation, further highlights the relevance of BAP1 as a clinically important tumor suppressor gene, and broadens the range of cancers associated with BAP1 inactivation | None |
| Bap1 is a bona fide tumor suppressor gene and offer key insights into the contribution of carcinogen exposure to enhanced cancer susceptibility | None |
| Different prognostic roles of tumor suppressor gene BAP1 in cancer: A systematic review with meta-analysis | None |
| Common, germline genetic variations in the novel tumor suppressor BAP1 and risk of developing different types of cancer | None |
| BAP1: case report and insight into a novel tumor suppressor | None |
| Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes | None |