| caspase-2 is a tumor suppressor in epithelial cancers such as breast cancer, and may be an important genetic marker for aggressive disease and poor prognosis. | breast, |
| loss of caspase-2 results in an increased ability of cells to acquire a transformed phenotype and become malignant, indicating that caspase-2 is a tumor suppressor protein. | None |
| caspase 2 functions as an endogenous inhibitor of NFkappaB-dependent cell survival and this mechanism may contribute to tumor suppression in humans. | None |
| Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice. | None |
| Caspase-2 showed tumor suppressive capacity in response to aberrant c-Myc expression, which did not rely on PIDD, the BH3-only protein Bid or the death receptor ligand Trail. | None |