| Sox7 is a tumor suppressor that functions as an independent checkpoint for beta-catenin transcriptional activity. Inactivation of Sox7 could promote the development of a majority of colorectal tumors and approximately half of prostate tumors. | colorectal,prostate, |
| SOX7 is a novel tumor suppressor gene silenced in the majority of NSCLC samples. | lung, |
| SOX7 acts as a tumor suppressor in breast cancer. | breast, |
| The expression of SOX7 correlates with tumor progression as a tumor suppressor, possibly through the Wnt/beta-catenin signaling pathway in ovarian cancers, suggesting that SOX7 may be a promising prognostic marker. | ovarian, |
| The results provided unequivocal evidence for a novel tumor suppressor role of SOX7 in acute myeloid leukemia | leukemia, |
| the HMG-box is a key domain of SOX7 for negatively regulating the Wnt/beta-catenin signaling pathway when functioning as a tumor suppressor in a glioma. | glioma, |
| Classic SRY-box protein SOX7 functions as a tumor suppressor regulating WNT signaling and is methylated in renal cell carcinoma | kidney, |
| we have identified an array of potential target genes of SOX7 and examined four of them for their roles in SOX7-mediated tumor suppression. We found that SOX7 could both activate and repress its target genes; and achieve its antiproliferative function through regulating multiple genes simultaneously. | None |