| SPOP plays a critical tumor suppressor role in prostate cancer cells, promoting the turnover of SRC-3 protein and suppressing androgen receptor transcriptional activity. | prostate, |
| studies highlight the AR axis as the key transcriptional output of SPOP in prostate adenocarcinoma and provide an explanation for the prostate-specific tumor suppressor role of wt-SPOP | prostate, |
| SPOP functions as a tumor suppressor to negatively regulate the stability of the ERG oncoprotein in prostate cancer. | prostate, |
| Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells | breast, |
| Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells | prostate, |
| Correction: Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer | prostate, |
| Loss of expression of SPOP gene might play a role in cancer pathogenesis by altering tumor suppressor gene functions of SPOP. | None |
| SPOP acts as a tumor suppressor by promoting senescence through degrading SENP7. | None |
| Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments | None |
| Data provide evidence that SPOP regulates lipid metabolism by decreasing FASN expression and FA synthesis, resulting in tumor suppression. | None |
| SPOP expression inhibited SRC-3-mediated oncogenic signaling and tumorigenesis. | None |