| The restoration of ECRG4 expression in ESCC cells inhibited cell proliferation, colony formation, cell cycle progression and tumor growth in vivo. ECRG4 is a novel candidate tumor suppressor gene in ESCC. | colorectal, |
| ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma. | colorectal,glioma, |
| Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion. | glioma, |
| ECRG4 is a candidate tumor suppressor gene which suppressed tumor cells migration and invasion without affecting cell adhesion ability in esophageal carcinoma. | esophageal, |
| A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma. | esophageal, |
| Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer. | breast, |
| ECRG4 is a candidate tumor suppressor gene in breast cancer | breast, |
| results suggest that C2ORF40 acts as a tumor suppressor gene in breast cancer pathogenesis and progression and is a candidate prognostic marker for this disease | breast, |
| ECRG4 is a candidate tumor suppressor gene that might be involved in the proliferation of esophageal squamous cell carcinoma | esophageal, |
| ECRG4 may be a tumor suppressor in renal cancer and serve as a prognostic marker | kidney, |
| ECRG4 as a novel tumor suppressor gene inhibits colorectal cancer cell growth in vitro and in vivo | colorectal, |
| UBR5 directly binds to the tumor suppressor esophageal cancer-related gene 4, increasing its ubiquitination to reducing the protein stability of ECRG4 to promote colorectal cancer progression. | colorectal,esophageal, |
| [Research progress of ECRG4 genes and molecular mechanism of tumor suppressor] | None |
| ECRG4 may act as a tumor suppressor, inhibiting proliferation and migration, inducing G0/G1 phase arrest and apoptosis via the mitochondrial apoptotic pathway. | None |
| the results help establish that phage display can be used to identify cryptic domains within ORFs of the human secretome and identify a novel TLR4-targeted internalization domain in the amino terminus of ECRG4 that may contribute to its effects on cell migration, immune cell activation and tumor suppression. | None |