| Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas. | sarcoma, |
| Results suggest different roles for CAV1 in SCLC, where CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears required for survival and growth. | lung, |
| Cav-1 functions as a tumor promoter during prostate carcinogenesis, rather than as a tumor suppressor | prostate, |
| Caveolin-1 acts as a tumor suppressor by down-regulating epidermal growth factor receptor-mitogen-activated protein kinase signaling pathway in pancreatic carcinoma cell lines. | pancreatic, |
| Global gene expression profiling and tissue microarray reveal novel candidate genes and down-regulation of the tumor suppressor gene CAV1 in sporadic vestibular schwannomas. | schwannomas, |
| E-cadherin has a role in regulating Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells | skin, |
| DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1, which PTRF, disrupts the MDM2/p53 complex, leading to apoptosis. | sarcoma, |
| Results indicate a central role for caveolin-1 in promoting cellular senescence and suggest the hypothesis that premature senescence may represent a tumor suppressor function mediated by caveolin-1 in vivo. | None |
| Results provide the first genetic evidence that caveolin-1 indeed functions as a tumor suppressor gene in vivo. | None |
| Cav-1 cooperates with the tumor suppressor INK4a genetic locus to prevent cell proliferation and oncogene-induced tumorigenesis | None |
| Cav-1 functions as a tumor suppressor in the stromal microenvironment. | None |
| a novel function of caveolin-1 in controlling COX-2 expression, which may regulate physiological functions and have tumor suppression effects. | None |
| Results suggest that CAV1 could function as a potent tumor suppressor in ARMS tumors. Inhibition of CAV1 function therefore, could contribute to aberrant cell proliferation, leading to ARMS development. | None |
| Interaction of Cav1 with its receptor EGFR inhibits signaling and reduces cell proliferation, supporting a tumor suppressor function for Cav1. | None |
| CAV-1 is commonly downregulated in patients with primary CRC, which suggests its tumor suppressor role in early stages of this disease. | None |
| Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3). Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/7q31). | None |
| Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing s sarcoma cells. | sarcoma, |
| QDs-IHC could accurately detect protein location in tongue mucosa. An increased expression of Cav-1 in the stepwise carcinogenesis from NTM, HTM, TPL to PTSCC suggested that Cav-1 might be an oncogene in the development of tongue squamous cell carcinoma. | tongue, |
| Expression of caveolin-1 in tongue squamous cell carcinoma by quantum dots. | tongue, |
| miR-133a is directly bound to CAV1 mRNA. Cancer cell migration and invasion were significantly inhibited in HNSCC cells transfected with si-CAV1. Therefore, CAV1 functions as an oncogene in HNSCC. | HNSC, |