| RUNX3 acts a tumor suppressor in chondrosarcoma and that RUNX3 promoter methylation may be the molecular mechanism for its decreased expression. | sarcoma, |
| Runx3 serves as both a tumor suppressor and promoter in slowing proliferation while orchestrating a metastatic program to stimulate cell migration, invasion, and secretion of proteins that favor distant colonization. | colorectal, |
| The hypermethylation of RUNX3 in AFB1-transformed hepatocytes and human hepatocellular carcinomas implicates RUNX3 as a tumor suppressor gene | liver, |
| These findings suggested that RUNX3 played a tumor suppressor role in oral squamous cell carcinoma (OSCC) by inhibiting cell migration, invasion and angiogenesis, supporting that it could be a potential therapeutic target for OSCC | oral |
| Methylation of tumour suppressor genes RUNX3, RASSF1A and E-Cadherin in HCV-related liver cirrhosis and hepatocellular carcinoma. | liver, |
| Data demonstrate that RUNX3 functions as a tumor suppressor by attenuating Wnt signaling. | None |
| ATBF1 associates with RUNX3 and translocates to the nucleus in response to TGF-beta signal transduction and might function in the nucleus as tumor suppressor and transcriptional regulator. | None |
| cyclin D1 provides a transcriptional switch that allows the tumor suppressor activity of RUNX3 to be repressed in cancer cells. | None |
| It is a tumor suppressor protein and plays a role as a coactivator of P53. | None |
| determined that the tumor suppressors CLU, NGFR, and RUNX3 were also directly repressed by EZH2 like CASZ1 in NB cells | None |
| Loss of tumor suppressors RUNX3 and CDKN2A were related to recurrence-risk and warrants further investigation | None |
| RUNX3 acts as a tumour suppressor | None |
| we present evidence that RUNX3 can act as a tumor suppressor in a human T-cell malignancy and suggest that this effect is predominantly mediated through transcripts from its distal promoter, in particular RUNX3/p46. | None |
| Post-translational modifications of RUNX3 have been shown to play an important role in directing RUNX3 functions. In cancer, RUNX3 functions as tumor suppressor or oncogene depending on its phosphorylation status by PAK1. [review] | None |
| Findings indicate that compared with the alcoholic steatohepatitis (ASH) group of patients, the expression levels of all three tumor suppressor genes (TSGs) proteins, RUNX family transcription factor 3 (RUNX3), glutathione S-transferase pi 1 (GSTP1), and RASSF1A tumor suppressor (RASSF1), were significantly lower in the non-alcoholic steatohepatitis (NASH) group of patients. | None |
| RUNX3 has an oncogenic role in head and neck cancer | HNSC, |
| RUNX3 has an oncogenic role in head and neck cancer. | HNSC, |
| Oncogenic role of RUNX3 in head and neck cancer. | HNSC, |
| RUNX3 functions as an oncogene in ovarian cancer. | ovarian, |
| RUNX3 is frequently expressed in the nuclei of ovarian cancer cell lines and plays an oncogenic role in ovarian cancer. | ovarian, |