| These findings suggested that SOCS-1 may act as a tumor suppressor in at least some colorectal cancers and that SOCS-1 methylation may be a particular phenomenon related to a nearly onset of colorectal cancer. | colorectal, |
| Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation | lymphoma, |
| mediastinal B-cell lymphoma and hodgkin lymphoma cells share overlapping features and defective tumor suppressor gene SOCS-1 triggers an oncogenic pathway operative in both Hodgkin and non-Hodgkin lymphomas. | lymphoma, |
| SOCS-1 mutations qualify as a tumor suppressor in mediastinal b-cell lymphoma. | lymphoma, |
| Data suggest that the Socs1 acts as classic tumor suppressor by preventing activation of STAT3; downregulation of Socs1 and consequent activation of STAT3 may be crucial in progression to hepatocellular carcinoma. | liver, |
| Our findings suggest a tumour suppressor-like role of SOCS1 in the hepatocarcinogenesis of human HCC. | liver, |
| SOCS1 gene is a direct target of miR-19a, which functions as an oncogenic miRNA in gastric cancer by repressing the expression of tumor suppressor SOCS1. | gastric, |
| tumor-suppressor functions of SOCS1 in the liver could be mediated, at least partly, via regulation of the expression, stability and subcellular distribution of p21 and its paradoxical oncogenic functions, namely, resistance to apoptosis and increased proliferation | liver, |
| Findings indicate that miR-21 and miR-155 promote the development of non-small cell lung carcinoma (NSCLC) in part by downregulating three tumor suppressor genes suppressor of cytokine signaling 1 protein (SOCS1), SOCS6, and PTEN. | lung, |
| Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer | prostate, |
| Association between methylation of tumor suppressor gene SOCS1 and acute myeloid leukemia | leukemia, |
| our results indicated that miR-29a worked as the tumor suppressor of cervical cancer via DNMT1-mediated methylation of tumor suppressor gene SOCS1, which suppressed NF-kappaB pathway for suppressing tumor cell proliferation, cell migration or invasion and accelerating apoptosis, although more in vivo evidences should be pursued to validate the proposed working model. | cervical, |
| The tumor suppressor activity of SOCS-1. | None |
| SOCS1 is a unique antioncogene which prevents chronic inflammation-mediated carcinogenesis by regulation of the IFNgamma/STAT1 pathways. | None |
| DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance. | None |
| The involvement of SOCS1 in p53 activation and the DNA damage response defines a novel tumor suppressor pathway | None |
| The Socs1 suppresses tumor formation in mammary glands by preventing the natural developmental function of a growth factor signaling pathway from becoming pro-oncogenic. | None |
| Findings indicate that SOCS1 mediates its tumor suppressor functions, at least partly, by binding to MET and interfering with downstream signaling pathways as well as by promoting the turnover of the activated MET receptor. | None |
| an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene. | None |
| Our findings support the tumor suppressor role of SOCS1 in PCa and suggest that attenuation of MET signaling is one of the underlying mechanisms. SOCS1 in PCa cells also appears to prevent the tumor-promoting functions of cancer-associated fibroblasts. | None |