| Beclin-1 acts as a tumor suppressor by regulating the hedgehog (HH) signaling pathway through Gli2 expression in gastric adenocarcinoma. | gastric, |
| some tumor suppressor functions of Beclin 1 were mediated through posttranscriptional regulation of ZEB1 via AUF1 in thyroid cancers. | thyroid, |
| Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. | None |
| Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. | None |
| Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. | None |
| beclin 1 is a critical component of mammalian autophagy, which has a role in tumor suppression | None |
| Evolutionarily conserved domain of Beclin 1 is essential for Vps34 interaction, autophagy function, and tumor suppressor function. | None |
| Control of autophagy by oncogenes and tumor suppressor genes. | None |
| Findings suggest a positive feedback loop for recruitment of FYVE-CENT and Beclin 1 to the intercellular bridge during cytokinesis, and reveal a novel potential tumor suppressor mechanism for Beclin 1. | None |
| Study provides a molecular mechanism involving protein deubiquitination that connects two important tumor suppressors, p53 and Beclin1. | None |
| These results demonstrate that Beclin1 acts as a tumour suppressor in the development or progression of OTSCC and that Beclin1 may represent a novel prognostic marker for patients with OTSCC. | None |
| Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination Cascades | None |