| TSC-22 normally contributes to the regulation of hematopoietic stem cell function and is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK LGL leukemia. | leukemia, |
| The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b. | None |
| TSC-22 is a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD | None |
| TSC-22 acts as a tumor suppressor by safeguarding p53 from poly-ubiquitination mediated-degradation. | None |