| By acting on cytokines and multiple proliferative pathways, SOCS3 modulates both physiological and neoplastic proliferative processes in the liver and may act as a tumor suppressor | liver, |
| SOCS3 is a tumor suppressor in breast cancer cells that is regulated by PRL | breast, |
| SOCS3 functions as a tumor suppressor gene in head and neck squamous cell carcinoma with relevance on proliferation and invasion processes. | HNSC, |
| SOCS3 impacts on IEC turnover following T. muris infection, potentially through enhancement of IDO. IDO may dampen the immune response which can drive intestinal epithelial cell hyperproliferation in the absence of SOCS3, demonstrating the intricate interplay of immune signals regulating mucosal homeostasis, and suggesting a novel tumour suppressor role of SOCS3. | None |