| This review summarizes the role of claudins in cancer and points out that claudin 1 (CLDN1) may support tumor suppressive functions in tissues such as the brain, where dramatic loss of CLDN1 expression has been demonstrated in glioblastoma multiforme. | glioblastoma,brain, |
| The tight junction protein claudin-1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3 | gastric, |
| Findings suggest that CLDN1 is oncogenic in gastric cancer and its malignant potential may be attributed in part to regulation of anoikis, by mediating membrane beta-catenin-regulated cell-cell adhesion and cell survival. | gastric, |