| Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers. | breast, |
| Loss of the expression of the tumor suppressor gene ARHI is associated with progression of breast cancer. | breast, |
| Association between STAT3 and ARHI as well as the functional inhibition of STAT3 transcriptional activity by ARHI suggests a novel mechanism through which a putative tumor suppressor gene can inhibit STAT3 activity in breast and ovarian cancers. | breast,ovarian, |
| E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. | breast, |
| Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. | ovarian, |
| provide evidences that ARHI downregulated in HCCs could play a role in liver cancer via acting as a tumor suppressor gene, which mainly was triggered by the epigenetic events in HCC specimens | liver, |
| The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. | ovarian, |
| Expression of the tumor suppressor ARHI inhibits the growth of pancreatic cancer cells by inducing G1 cell cycle arrest. | pancreatic, |
| The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways. | ovarian, |
| ARHI expression is downregulated in human gastric cancer and it may be a novel tumor suppressive target for gastric cancer therapy. | gastric, |
| ARHI acts as a tumor suppressor by downregulating the NFkappaB signaling pathway, which results in the inhibition of cell proliferation, apoptosis and the cell cycle in the pancreatic tumor PANC-1 cell line | pancreatic, |
| The data indicate that JMJD2A could promote breast cancer progression through transcriptional repression of the tumor suppressor ARHI. | breast, |
| ARHI is a novel epigenetic silenced tumor suppressor in sporadic pheochromocytoma | PCPG, |
| Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer. | breast, |
| Study found that both autophagy and apoptosis were induced after over-expressing ARHI in glioma cells suggesting that ARHI may be a functional tumor suppressor in glioma. | glioma, |
| NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. | breast,ovarian, |
| Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI. | None |
| ARHI acts as a tumor suppressor gene in MDA-MB-231 cells and, although trichostatin A+5-aza-2_-deoxycytidine can block the cells at different cell cycle phase, the antitumor effect is ARHI-dependent. | None |
| a novel oncogenic role of DIRAS3 in the development and progression of glioma | glioma, |