| Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma. | sarcoma, |
| These results indicate that LATS1 is an important candidate tumor suppressor and its downregulated expression may contribute to glioma progression | glioma, |
| Our findings suggest that LATS1 is a potential candidate tumor suppressor and inhibits the growth and metastasis of gastric carcinoma cells via downregulation of the YAP signaling. | gastric, |
| Clinicopathological Significance of Large Tumor Suppressor (LATS) Expression in Gastric Cancer | gastric, |
| A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1 | breast, |
| Data show NF-kappa-B (NFkappaB) is required to initiate pancreatic epithelial-mesenchymal transition (EMT) downstream of large tumor suppressor kinases 1 and 2 (Lats1/2) deletion. | pancreatic, |
| A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. | None |
| Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. | None |
| WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis. | None |
| Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor. | None |
| C-terminal Src kinase (CSK) in Drosophila was identified in a genetic modifier screen for genes that interact with the lats tumor suppressor gene. CSK regulates cell proliferation and organ size. | None |
| Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. | None |
| The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. | None |
| Activation of Omi / HtrA2-mediated cell death is a potential mechanism for the tumor suppressive activity of WARTS. | None |
| The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death. | None |
| Here, we show that warts, encoding large tumor suppressor (Lats) and melted encoding a PH-domain protein, play opposite roles in defining the yR 8 or pR8 fates in Drosophila ommatidia photoreceptors. | None |
| Tumor suppressor LATS1 is a negative regulator of oncogene YAP. | None |
| Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice. | None |
| The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. | None |
| KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif | None |