| Our findings underscore a potent oncogenic role for GEF-H1 in promoting the metastatic potentials of hepatocellular carcinoma, possibly through activation of RhoA signalling. | liver, |
| Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells. | None |
| APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis. | None |
| The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1. | None |
| Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C. | None |