| Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). | HNSC, |
| Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity. | glioma, |
| The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer. | breast, |
| oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer | breast, |
| MiR-30d induces apoptosis and is regulated by the Akt/FOXO pathway in renal cell carcinoma. | kidney, |
| data suggest that miR-542-3p might function as a tumor suppressor in gastric cancer, potentially by targeting the oncogene AEG-1 | gastric, |
| MicroRNA-542-3p suppresses cell growth of gastric cancer cells via targeting oncogene astrocyte-elevated gene-1. | gastric, |
| Data established that AEG-1 is frequently upregulated and functions as an oncogene by regulating several major signaling pathways in hepatocellular carcinoma (HCC) suggesting potential role as a biomarker or target for HCC therapy. [review] | liver, |
| Findings clearly demonstrate that miR-320a suppresses breast cancer metastasis by directly inhibiting MTDH expression. The present study provides a new insight into anti-oncogenic roles of miR-320a. | breast, |
| Study showed that AEG-1_s knock down inhibited cell growth, triggered apoptosis, arrested cell cycle, retarded cell migration and invasion in ovarian cancer cells. These results provide evidence that AEG-1 plays an oncogenic role in ovarian cancer cells. | ovarian, |
| oncogenic role of AEG-1 in melanoma | skin, |
| Study found that miR-30e was correlated with the aggressive characteristics in patients with squamous cell carcinoma of the head and neck (SCCHN), which was an independent factor for prognosis in patients with SCCHN. miR-30e directly targeted oncogene AEG-1, impeding the invasion and metastasis of SCCHN via the modulation of both epithelial-mesenchymal transformation occurrence and cancer angiogenesis. | HNSC, |
| AEG-1 is an oncogene cooperating with Ha-ras as well as functioning as a downstream target gene of Ha-ras; may perform a central role in Ha-ras-mediated carcinogenesis. | None |
| Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. | None |
| Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. | None |
| findings demonstrate that aberrant AEG-1 expression plays a dominant positive role in regulating oncogenic transformation and angiogenesis | None |
| historical perspective of AEG-1; evaluation of AEG-1 as a novel diagnostic/prognostic biomarker for a variety of cancers; understanding of the molecular and biochemical bases of oncogenic properties of AEG-1 [review] | None |
| As an oncogene that promotes aberrant cellular processes within the CNS, AEG-1/MTDH/LYRIC represents an important therapeutic target for the treatment of neurological disease. [review] | None |
| Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491. | None |
| MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors. | None |